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REVIEW ARTICLE
Year : 2014  |  Volume : 1  |  Issue : 1  |  Page : 16-18

Fertility preservation for ovarian or uterine cancer patients with reference to assisted reproduction technology


Head and Chief Embryologist, Thomson Fertility Centre, Singapore

Correspondence Address:
Dr. Ethiraj Balaji Prasath
Thomson Fertility Centre, Novena Specialist Center, # 07-02, 8, Sinaran Drive 307470
Singapore
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2394-4285.146701

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Fertility preservation has been paid much attention recently, as the survival rate of cancer patients after therapy has increased significantly. Cryopreservation of gametes or embryos has been practiced prior to cancer therapy, to preserve fertility, as various modes of cancer therapy are gonadotoxic, reducing reproductive potential of cancer survivors. Although cryopreserving semen or testicular tissue has been the prominent means of fertility preservation for men, it has been still experimental for pre-pubertal boys. Treating by Assisted reproduction Techniques with cryopreservation of oocytes or embryos is the promising way of fertility preservation in women prior to cancer therapy. Livebirths have been reported after auto transplantation of cryopreserved ovarian cortex. Such an approach may not be practical in women with ovarian or endometrial or Estrogen sensitive breast cancer as transplantation of ovarian cortex may reintroduce the disease. Oophorectomy in such patients is not uncommon leading to total infertility of patients. Alternative approaches are available to preserve fertility of such women. Harvesting oocytes for cryopreservation in women without male partners or embryos after in vitro maturation and ICSI of harvested oocytes in women with male partners have been reported as modern means of fertility preservation in ovarian cancer patients. Efficacy of such approaches is reviewed in this article.


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