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CASE REPORT
Year : 2015  |  Volume : 2  |  Issue : 1  |  Page : 40-42

Pregnancy in a lady with premature ovarian failure following dehydroepiandrosterone (DHEA) treatment


1 Director and Chief Fertility Consultant, Calcutta Fertility Mission, Kolkata, India
2 Consultant, Department of Obstetrics and Gynaecology, PG-ESI Hospital, Manicktala, Kolkata, India
3 Assistant Professor, Surgical Gynaecology, Sagar Dutta Medical College, Kamarhati, Kolkata, India
4 Consultant Gynaecologist, Calcutta Fertility Mission, Kolkata, West Bengal, India

Correspondence Address:
Siddhartha Chatterjee
21, Bondel Road, Kolkata - 700 019, West Bengal
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2394-4285.180507

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Poor responders are real challenges for infertility physicians, as they produce lesser numbers of oocytes after ovulation stimulation. Fertility begins to decline after 30 years of age in women. Hence, in elderly women, diminution of ovarian reserve is a reality. Diminished ovarian reserve (DOR) may be found in young women as well. Ovarian reserve test (ORT) are many, but among them, estimation of follicle-stimulating Hormone (FSH), antral follicle count (AFC) by ultrasound, and estimation of anti-Müllerian Hormone (AMH) are far more standardized. In recent years, one of the androgens called dehydroepiandrosterone (DHEA) has been tried to elevate ovulatory response in DOR patients. DHEA mostly brings the sleeping follicular pool to functional pool and prevents apoptosis of many follicles, thereby, promoting ovulatory response of ovaries with diminished ovarian functions. One such case with premature ovarian failure (POF) has been presented here, who conceived after DHEA treatment. Though escape ovulation can happen in postmenopausal patients, here the lady conceived with DHEA treatment 7 years after achieving premature menopause, during which she suffered from complete secondary amenorrhea.


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