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ORIGINAL ARTICLE
Year : 2019  |  Volume : 6  |  Issue : 2  |  Page : 120-125

Age-dependent decline of anti-Müllerian hormone (AMH) in a large population of Indian fertile women as measured using the automated VIDAS® AMH assay


1 Department of Reproductive Medicine, Mother and Child, India
2 Mother and Child Hospital, New Delhi, India
3 BioMérieux SA, Chemin de L’Orme, Marcy L’Etoile, France

Correspondence Address:
Dr. Jasneet Kaur
Department of Reproductive Medicine, Mother and Child Hospital, New Delhi
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/fsr.fsr_35_19

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Background: Serum anti-Müllerian hormone (AMH) testing is now routine practice to assess the ovarian follicular reserve and to predict the response to controlled ovarian stimulation (COS) for assisted reproductive technique (ART). Reference values for a new AMH assay should take into account possible genetics and environmental factors that can be observed in a given population/geographical region such as India. Objectives: Primary objective was to observe the inter-individual variability of AMH in a large sized cohort of fertile Indian women as measured with the automated VIDAS® AMH assay, to model the age-dependent decline of AMH across the reproductive age range and to establish the reference values for this assay for an Indian female population. Secondary objective was to study the possible relationships between AMH and other parameters such as Vitamin D status and body mass index (BMI). Materials and methods: Serum AMH and Vitamin D concentrations were measured using VIDAS® AMH and VIDAS® 25 OH Vitamin D Total assays, in a cohort of 975 fertile Indian women aged 19–50 years. Correlations between AMH and age, Vitamin D, and BMI were also analyzed. Results: Reference AMH values for the VIDAS® AMH assay are reported as an AMH/age nomogram, including a model fitting the age-dependent decline of the hormone. For 66.26% of these women, a Vitamin D deficiency was observed. Discussion and conclusion: Reference values representative of Indian women are reported using VIDAS® AMH assay that can help the clinicians for the management of their Indian patients consulting for endocrinology and fertility disorders across the reproductive age range. The cross-sectional data analysis of the Vitamin D status has shown a predominant deficiency for these fertile women.


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