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Year : 2015  |  Volume : 2  |  Issue : 2  |  Page : 143-149

Preovulatory normal saline pertubation prior to intrauterine insemination increases conception rate in unexplained infertility

1 Department of Obstetrics and Gynecology, Maulana Azad Medical College, New Delhi, India
2 Department of Obstetrics and Gynecology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India

Correspondence Address:
Dr. Sudha Prasad
Bungalow No. 02, New Moti Bagh, Shanti Path, New Delhi - 110 021
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2394-4285.196788

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Context: Intrauterine insemination (IUI) is widely used for fertility management for unexplained infertility (UI). Washed sperm are placed into uterine cavity to achieve pregnancy. The success rate of IUI with combined ovulation induction is always debated. Aims: The aim of the study is to analyze the effect of preovulatory pertubation with lignocaine, normal saline versus no-pertubation on conception rate during IUI cycle in women with UI. Settings and Design: A prospective, randomized controlled trial was conducted at University hospital tertiary referral center. Subjects and Methods: Of 464 women with UI, 320 women who fulfilled inclusion criteria were enrolled in the study. Ovulation induction was started with appropriate protocol. Women underwent transvaginal sonography till they achieved 2–3 dominant follicles of size ≥17–18 mm and endometrial thickness of ≥7 mm. Randomization was done by chit-pull system into three groups. Pertubation was carried out with low dose lignocaine or normal saline after 12–14 h of human chorionic gonadotropin administration. Pertubation groups were compared with no-pertubation IUI group. Statistical Analysis: Data were compared with unpaired Student’s t-test and Chi-square test appropriately. Results: Conception rate was 7.4% in lignocaine group, 20.7% in normal saline group, and 10.3% in control group. Conclusions: Pertubation with normal saline was associated with significant increase in IUI conceptions and live births as compared to no-pertubation group. Lignocaine pertubation was associated with the lowest conception rates but outcomes were not significantly different from the control. Hence, preovulatory saline pertubation prior to IUI is recommended to improve pregnancy rates in UI.

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