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Year : 2020  |  Volume : 7  |  Issue : 1  |  Page : 78-84

To assess serum Anti Mullerian Hormone (AMH) level as a biomarker for oocyte quality

Southend Fertility and IVF, Delhi, India

Correspondence Address:
Dr. Aneesha M Grover
DNB Obs and Gyn, MSc Clinical Embryology, IFS Fellow Clinical ART, Southend Fertility and IVF, Delhi
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2394-4285.288719

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Introduction: Oocyte competence is a factor that affects ART outcomes. Oocyte morphology assessment and scoring are laborious, have inter-observer variations and lack consensus on parameters to be assessed. Role of anti mullerian hormone (AMH) as a biomarker for oocyte quality and competence is investigated. Aim and Objectives: To evaluate day 2/3 serum AMH as a predictor of oocyte quality, embryo quality and fertilization rate in a stimulated ART cycle. Methods: Single centre, prospective observational study. All patients undergoing IVF-ICSI between August 2018 and February 2019 included. Total Oocyte Score calculated for all oocytes. and subsequently assessed for fertilization, cleavage and day 3 embryo grading. Correlations between AMH levels and TOS, PTOS, Fertilization and Cleavage rates assessed using appropriate statistical methods. Results: Of 86 patients and 780 oocytes studied,639 underwent ICSI with fertilization rate 86% (550/639) and cleavage rate 90.7%(499/550). Embryo grades were A-50.6%, B-38.9% and C-10.5%. Mean TOS score and PTOS scores were 0.3±1.99 and 0.44±1.21.TOS was predictive of fertilization [ROC-AUC=0.598(P = 0.004)]. Mean AMH levels were 3.66 ± 3.96 ng/ml [0.69±0.21ng/ml<25th centile, 2.74±1.14 ng/ml, 25th–75th centile, 8.27±5.08ng/ml>75th centile] and decreased with increasing age. AMH levels correlated with TOS, PTOS, fertilization and cleavage rates. The r2 values were low suggesting poor clinical significance. AMH levels were not predictive of fertilization and embryo grade. Conclusion: AMH levels show weak correlation with oocyte quality and are poor predictor of oocyte competence.

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