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ORIGINAL ARTICLE
Year : 2020  |  Volume : 7  |  Issue : 2  |  Page : 141-146

To study the effect of autologous platelet-rich plasma instillation on suboptimal endometrium and pregnancy outcomes in infertile women undergoing frozen embryo transfer cycle


1 Institute of Reproductive Medicine and IVF Centre, Primus Super Specialty Hospital, Delhi, India
2 MD, Institute of Reproductive Medicine and IVF Centre, Primus Super Specialty Hospital, Delhi, India

Correspondence Address:
Dr. R.K. Sharma
Primus Super Specialty Hospital, Chandragupta Marg, Chanakyapuri, Delhi
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/fsr.fsr_10_20

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Introduction:This pilot study was done to evaluate the effectiveness of intrauterineinstillation of autologous platelet rich plasma in the treatment of infertile woman with ≥2 IVF failures due to thin endometrium not responding to empirical medical therapies. Design: Prospective interventional study. Material and Methods: Intra uterine instillation of PRP was done in 50 women between 23 to 38 years with suboptimal endometrial receptivity, ≥ 2 IVF failures and HRT cycle cancellations over a course of 9 months. Frozen embryo transfer was done when optimal endometrial thickness and vascularity was achieved. Results: The mean endometrial thickness pre PRP was 5.78mm which increased to 7.20mm post-PRP (P value < 0.001). There was a statistically significant increase in endometrial vascularity. The mean PI uterine artery pre-PRP was 3.18 which decreased to 2.71 post PRP (P-value < 0.001). There was a statistically significant fall in uterine artery RI from 1.04 to 0.86 after PRP therapy. The implantation rate, clinical pregnancy rate were 15.3% & 33.3% respectively. One patient had early clinical pregnancy loss. Cervical ectopic pregnancy was diagnosed in 1 patient. 4 patients had DADC twins. Conclusion: PRP is a safe, inexpensive and acceptable alternative for endometrial preparation of infertile patients with ≥2 IVF failures due to suboptimal endometrium.


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