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ORIGINAL ARTICLE
Year : 2020  |  Volume : 7  |  Issue : 2  |  Page : 162-168

To study the comparison of efficacy of letrozole versus clomiphene citrate for ovulation induction in infertile women with PCOS in Indian population


Department of Reproductive Medicine, Akanksha IVF Centre, Mata Chanan Devi Hospital, Janakpuri, New Delhi, India

Correspondence Address:
Dr. Eshna Gupta
Fellow in Clinical ART, Room no. 711, Department of Reproductive Medicine, Akanksha IVF Centre, Mata Chanan Devi Hospital, C-1, Janakpuri, New Delhi
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/fsr.fsr_23_20

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Background: The aim of the study was to study the comparison of the efficacy of letrozole versus clomiphene citrate (CC) for ovulation induction in infertile women with polycystic ovary syndrome (PCOS) in Indian population. Methods: This prospective trial included 92 infertile women with PCOS. Letrozole dose of 2.5 mg/day (n = 47) or a CC dose of 100 mg/day (n = 45) was given from day 3 to day 7 of the menstrual cycle. Follicular monitoring was started from day 7 and done until the mean diameter of the largest follicle reached 18 mm, then, 5000 IU of human chorionic gonadotropin (HCG) was given. Intrauterine insemination was done in two sittings, 24 and 48 hours after HCG. Statistical testing was conducted with SPSS 17.0. Results: The clinical profile of patients belonging to both groups were comparable. The number of follicles ≥18 mm on the day of HCG was 1.11 ± 0.43 for the letrozole group and 2.53 ± 1.10 for the CC group (P<0.001). Endometrial thickness on the day of HCG administration (mm) was higher in the letrozole group than the CC group (P<0.001). Ovulation rate was higher in the letrozole group (P = 0.047). Urine pregnancy test (UPT) positive patients were 40.42% in the letrozole group and 20% in the CC group (P = 0.033). Clinical pregnancy rates were slightly higher in the letrozole group. Higher twin pregnancy (P = 0.025) and miscarriage rates were noted in the CC group (P = 0.033). Conclusion: Letrozole appears to be superior to CC for ovulation induction in infertile PCOS patients.


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