• Users Online: 243
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Archives Submit article Instructions Referee Resource Subscribe
ORIGINAL ARTICLE
Year : 2020  |  Volume : 7  |  Issue : 2  |  Page : 169-174

Effect of hyaluranon-rich medium for embryo transfer on IVF outcome in patients with recurrent implantation failure


Department of Reproductive Medicine, Akanksha IVF Centre, Mata Chanan Devi Hospital, Block C-1, Janakpuri, New Delhi, India

Correspondence Address:
Dr. Nidhi Sharma
Room No. 711, Department of Reproductive Medicine, Akanksha IVF Centre, Mata Chanan Devi Hospital, C-1, Janakpuri, New Delhi
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/fsr.fsr_28_20

Rights and Permissions

Objective: The aim of the study was to evaluate efficacy of hyaluronan-rich medium on implantation and clinical pregnancy rates in vitrified-warmed blastocyst transfers in recurrent implantation failure patients. Methods: This was a randomized controlled study conducted at Akanksha IVF Centre, New Delhi. One hundred patients with history of previous two or more implantation failures, with at least one implantation failure at the present center, were included in the study. Patients were randomly divided into two groups: study group (n = 37) had embryos transferred into 20 μL of EmbryoGlue for 10 minutes prior to transfer inside uterine cavity. In the control group (n = 31), embryos were transferred to the conventional blastocyst culture medium. Statistical analysis was performed using Statistics Package for Social Sciences. Results: The patient’s mean age, causes of infertility, serum anti-Müllerian hormone level, embryo quality and the number of transferred embryos were comparable between the study and control groups. The clinical pregnancy rate in study group was higher than control group (40.5% vs 25.8%). However, the difference was not statistically significant (P = 0.58). There was no statistically significant improvement in implantation rate (44% vs 34.1%; P = 0.32), miscarriage rate (6.6% vs 12.5%; P = 0.27) and multiple pregnancy rate (13.3% vs 12.5%; P = 0.9). Conclusion: The use of EmbryoGlue in transfer medium in the blastocyst transfer in vitrified-warmed cycles does not have any significant effect on the implantation and pregnancy rates in patients with previous implantation failure.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed976    
    Printed22    
    Emailed0    
    PDF Downloaded93    
    Comments [Add]    

Recommend this journal