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ORIGINAL ARTICLE
Year : 2020  |  Volume : 7  |  Issue : 2  |  Page : 190-198

Effect of intrauterine administration of human chorionic gonadotropin (hCG) before embryo transfer on biochemical pregnancy rate, implantation rate, and clinical pregnancy rate in in vitro fertilization/intracytoplasmic sperm injection cycles: Prospective and interventional randomized comparative study


Origyn Fertility and IVF Centre, New Delhi, India Sawai Mansingh Hospital, Jaipur; University College Of Medical Sciences, New Delhi, India

Correspondence Address:
Dr. Imlesh Meena
Origyn Fertility And Ivf Centre, New Delhi
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/fsr.fsr_37_20

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Objective: To study the effect of intrauterine administration of human chorionic gonadotropin (hCG) before embryo transfer (ET) on biochemical pregnancy rate, implantation rate, and clinical pregnancy rate in in vitro fertilization/intracytoplasmic sperm injection cycles. Design: Prospective and interventional randomized comparative study. Setting: Origyn Fertility & IVF, 4th floor, HB Twin towers, Netaji Subhash Place, Above Max Hospital Pitampura, New Delhi. Patients: All patients aged 23 to 38 years undergoing fresh or frozen ET or planned for in vitro fertilization/intracytoplasmic sperm injection cycle are included in the study. Intervention: From August 2019 to March 2020, 80 patients were included in the study who were divided into two subgroups viz group “A” (Case group) and group “B” (control group). Group “A” patients were given 500 IU of hCG intrauterine 7 min prior to ET and in group “B” patients, the embryo was transferred directly. Outcome measure: Biochemical pregnancy rate, clinical pregnancy rate, and implantation rate. Results: Clinical pregnancy rate was 52.5% in the case group and 45% in the control group. Biochemical pregnancy rate was 57.5% in the case group and 52.5% in the control group. Mean implantation rate was 30.41 ± 36.57 in the case group and 24.57 ± 30.42 in the control group. Conclusion: The intrauterine instillation of 500 IU of hCG 7 min before ET did not show any significant difference in clinical pregnancy rate, biochemical pregnancy rate, and implantation rate. However, as this study was performed on a small group, its reliability in clinical practice needs further studies on a larger study group.


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