| ORIGINAL ARTICLE |
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| Year : 2020 | Volume
: 7
| Issue : 2 | Page : 199-203 |
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To study the role of growth hormone supplementation on endometrial response and implantation rate in frozen thawed embryo transfer (FET) cycles
Rupali Khanna, Madampath Gouri Devi, Meeta Sharma
Ridge IVF Pvt. Ltd., Delhi, India
Correspondence Address:
Dr. Rupali Khanna
D-71, Mansarovar Garden, New Delhi 110015
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/fsr.fsr_38_20
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Aim: To assess the role of growth hormone in improving endometrial response and clinical outcome. Materials and Methods: A prospective randomised study was conducted with 50 patients who were treated with FET cycles at Ridge IVF, Delhi, between August 2019 and January 2020. Patients were classified into two groups: group A administered simultaneous GH along with hormone-replacement therapy (HRT), for endometrial preparation; while group B received HRT alone. GH four IU subcutaneously was started on the day of HRT (day two/three) and continued till the endometrium reached a thickness of 8 mm. Statistical analysis: Statistical testing was conducted with the statistical software SPSS 20.0. Continuous variables are presented as mean±SD. Categorical variables are expressed as frequencies and percentages. Categorical data was compared using Chi-square test or Fisher’s exact test as appropriate. Results: Patients in group A had a significantly higher endometrial thickness (8.86±1.06 mm) as compared to group B (8.34±1.16 mm) (P value=0.028). However, patients in group A i.e those given GH, had a lower impedance to blood flow as shown by a lower pulsatility index (1.68±0.12 vs 1.92±0.13) (P value=0.028), resistance index (0.73±0.06 vs 0.86±.02) (P value=0.053), and a lower peak systolic velocity/end diastolic velocity of the uterine arcuate artery (2.68±.13 vs 2.93±0.11) (P value=0.066). The clinical pregnancy rate was comparatively more in group A compared to group B (56% vs 48%) (P value=0.588). Conclusion: Growth hormone when given along with HRT can improve FET results by enhancing endometrial perfusion.
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