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   Table of Contents - Current issue
January-March 2023
Volume 10 | Issue 1
Page Nos. 1-60

Online since Friday, March 31, 2023

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Editors view point p. 1
Kuldeep Jain
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Bell Jar to Cloud p. 2
Pankaj Talwar, Meenu Vashisht Ahuja
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Challenges of OHSS in modern reproductive medicine practice p. 6
Raj Mathur
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The role of genotoxicity in infertility and cancer development p. 9
Kanad Dev Nayar, Sabina Sanan, Ankita Sethi, Sakshi Miglani, Gaurav Kant, Kapil Dev Nayar
According to recent literature, genotoxicity is one of the important causes of infertility and the rising incidence of various cancers worldwide. DNA damage and its effect on DNA segregation are the mechanisms by which genotoxicity causes infertility or carcinogenesis. In this article, we discuss about genotoxicity and the various chemicals and environmental pollutants that cause genetic damage and their mechanisms of action. Hazardous effects of chemicals and pollutants can be evaluated by various genotoxicity and mutagenicity tests. These are important and initial steps in industrial development and the regulation of their effect on health. The detailed knowledge of the effects of genotoxins on fertility at the molecular, subcellular, cellular and tissue or organ system levels is crucial for a better understanding of occupational and environmental hazards and the need to find safe alternatives. In addition, new biomarkers using OMICS can render genotoxicity evaluation to decrease the infertility and cancer risk.
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Time line in IVF laboratory p. 15
Ethiraj Balaji Prasath
The time line in IVF is critical, as the procedures are associated with the time of the ovulation trigger for follicular maturation, followed by sequential procedures in relation to it. Starting from oocyte recovery scheduled 36 hours post-trigger, the laboratory procedures are followed up sequentially. Oocyte cumulus complex (OCC) may be incubated until insemination or ICSI until 40 hours post-trigger. Conventional insemination may be done either short (4–6 hours) or long insemination (overnight). However, short insemination is associated with an increase in the 3-PN rate. OCC for ICSI may be denuded at least after 38 hours post-trigger, and ICSI may be performed within 2 to 4 hours post-denuding. ICSI done within 2 hours post-denuding appears to be yielding better-quality embryos. Time-lapse studies have indicated that it is possible to obtain higher clinical and live birth rates with embryos reaching the blastocyst stage faster than other embryos. Embryo transfers done with Day 3 embryos result in a higher pregnancy rate than Day 2 while blastocyst transfers perform better than day 3 transfers. Mobilization of patients after ET may not affect the outcome.
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Fertivision 2022- Oral Papers Abstracts p. 20
Garima Patel, Neeta Singh, Neena Malhotra, Reeta Mahey
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Fertivision 2022- Poster Abstracts p. 60
Garima Kaur, Kanad Dev Nayar
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